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TLM Kolkata Hospital was established in the year 1986.

This hospital was started by Rev. Premananda Ananth Nath Sen, a Hindu convert, as a treatment centre for leprosy sufferers, on a corner of a Christian cemetery in Kolkata. The Oxford Mission which ran the clinic after the death of Rev. Sen handed over the clinic to The Leprosy Mission Trust India which had started a leprosy control unit in Kolkata in 1980, working from rented premises. The hospital building was built in 1986. It is recognised as a referral hospital for leprosy-related complications by the government, private medical practitioners, and other NGOs.

The facilities provided by the hospital include out-patient facilities, in-patient facilities, operating theatre, laboratory services, ECG services, X-ray services, counselling, physiotherapy, pharmacy, MCR protective footwear and artificial limbs.